The yeast Sup35NM domain propagates as a prion in mammalian cells

Prions are infectious, self-propagating amyloid-like protein aggregates of mammals and fungi. We have studied aggregation propensities of a yeast prion domain in cell culture to gain insights into general mechanisms of prion replication in mammalian cells. Here, we report the artificial transmission...

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Detalhes bibliográficos
Main Authors: Krammer, Carmen, Kryndushkin, Dmitry, Suhre, Michael H., Kremmer, Elisabeth, Hofmann, Andreas, Pfeifer, Alexander, Scheibel, Thomas, Wickner, Reed B., Schätzl, Hermann M., Vorberg, Ina
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2626725/
https://ncbi.nlm.nih.gov/pubmed/19114662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811571106
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