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Direct conversion of fibroblasts to functional neurons by defined factors

Cellular differentiation and lineage commitment are considered robust and irreversible processes during development. Recent work has shown that mouse and human fibroblasts can be reprogrammed to a pluripotent state with a combination of four transcription factors. This raised the question of whether...

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Bibliografische gegevens
Hoofdauteurs: Vierbuchen, Thomas, Ostermeier, Austin, Pang, Zhiping P., Kokubu, Yuko, Südhof, Thomas C., Wernig, Marius
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829121/
https://ncbi.nlm.nih.gov/pubmed/20107439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08797
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