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Direct conversion of fibroblasts to functional neurons by defined factors

Cellular differentiation and lineage commitment are considered robust and irreversible processes during development. Recent work has shown that mouse and human fibroblasts can be reprogrammed to a pluripotent state with a combination of four transcription factors. This raised the question of whether...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Vierbuchen, Thomas, Ostermeier, Austin, Pang, Zhiping P., Kokubu, Yuko, Südhof, Thomas C., Wernig, Marius
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829121/
https://ncbi.nlm.nih.gov/pubmed/20107439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08797
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