Ku Regulates the Non-Homologous End Joining Pathway Choice of DNA Double-Strand Break Repair in Human Somatic Cells

The repair of DNA double-strand breaks (DSBs) is critical for the maintenance of genomic integrity and viability for all organisms. Mammals have evolved at least two genetically discrete ways to mediate DNA DSB repair: homologous recombination (HR) and non-homologous end joining (NHEJ). In mammalian...

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Bibliographic Details
Main Authors: Fattah, Farjana, Lee, Eu Han, Weisensel, Natalie, Wang, Yongbao, Lichter, Natalie, Hendrickson, Eric A.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829059/
https://ncbi.nlm.nih.gov/pubmed/20195511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000855
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