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A role for XLF in DNA repair and recombination in human somatic cells
Classic non-homologous end-joining (C-NHEJ) is required for the repair of radiation-induced DNA double-strand breaks (DSBs) in mammalian cells and plays a critical role in lymphoid V(D)J recombination. A core C-NHEJ component is the DNA ligase IV co-factor, Cernunnos/XLF (hereafter XLF). In patients...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3948327/ https://ncbi.nlm.nih.gov/pubmed/24461734 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2013.12.006 |
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