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A role for XLF in DNA repair and recombination in human somatic cells

Classic non-homologous end-joining (C-NHEJ) is required for the repair of radiation-induced DNA double-strand breaks (DSBs) in mammalian cells and plays a critical role in lymphoid V(D)J recombination. A core C-NHEJ component is the DNA ligase IV co-factor, Cernunnos/XLF (hereafter XLF). In patients...

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Detalhes bibliográficos
Main Authors: Fattah, Farjana, Kweon, Junghun, Wang, Yongbao, Lee, Eu Han, Kan, Yinan, Lichter, Natalie, Weisensel, Natalie, Hendrickson, Eric A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948327/
https://ncbi.nlm.nih.gov/pubmed/24461734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2013.12.006
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