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A role for XLF in DNA repair and recombination in human somatic cells
Classic non-homologous end-joining (C-NHEJ) is required for the repair of radiation-induced DNA double-strand breaks (DSBs) in mammalian cells and plays a critical role in lymphoid V(D)J recombination. A core C-NHEJ component is the DNA ligase IV co-factor, Cernunnos/XLF (hereafter XLF). In patients...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3948327/ https://ncbi.nlm.nih.gov/pubmed/24461734 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2013.12.006 |
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