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Metabolic control of G1–S transition: cyclin E degradation by p53-induced activation of the ubiquitin–proteasome system

Cell cycle progression is precisely regulated by diverse extrinsic and intrinsic cellular factors. Previous genetic analysis in Drosophila melanogaster has shown that disruption of the mitochondrial electron transport chain activates a G1–S checkpoint as a result of a control of cyclin E by p53. Thi...

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Detalhes bibliográficos
Main Authors: Mandal, Sudip, Freije, William A., Guptan, Preeta, Banerjee, Utpal
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828916/
https://ncbi.nlm.nih.gov/pubmed/20176921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200912024
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