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Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1
The tumor suppressor p53 is a labile protein whose level is known to be regulated by the Mdm-2–ubiquitin–proteasome degradation pathway. We have found another pathway for p53 proteasomal degradation regulated by NAD(P)H quinone oxidoreductase 1 (NQO1). Inhibition of NQO1 activity by dicoumarol induc...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC130597/ https://ncbi.nlm.nih.gov/pubmed/12232053 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.202480499 |
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