Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1

The tumor suppressor p53 is a labile protein whose level is known to be regulated by the Mdm-2–ubiquitin–proteasome degradation pathway. We have found another pathway for p53 proteasomal degradation regulated by NAD(P)H quinone oxidoreductase 1 (NQO1). Inhibition of NQO1 activity by dicoumarol induc...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Asher, Gad, Lotem, Joseph, Sachs, Leo, Kahana, Chaim, Shaul, Yosef
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2002
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC130597/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12232053/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.202480499
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