Oxygen Tension Regulates Pancreatic β-Cell Differentiation Through Hypoxia-Inducible Factor 1α

OBJECTIVE: Recent evidence indicates that low oxygen tension (pO(2)) or hypoxia controls the differentiation of several cell types during development. Variations of pO(2) are mediated through the hypoxia-inducible factor (HIF), a crucial mediator of the adaptative response of cells to hypoxia. The a...

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Bibliographic Details
Main Authors: Heinis, Mylène, Simon, Marie-Thérèse, Ilc, Karine, Mazure, Nathalie M., Pouysségur, Jacques, Scharfmann, Raphael, Duvillié, Bertrand
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2010
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828660/
https://ncbi.nlm.nih.gov/pubmed/20009089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0891
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