Transduction of Liver Metastases After Intravenous Injection of Ad5/35 or Ad35 Vectors With and Without Factor X-Binding Protein Pretreatment

Inefficient tumor transduction with targeted adenoviral vectors is largely due to unspecific virus sequestration by blood components, including coagulation factor X, and Kupffer cell scavenging. In this study, we show that preinjection of snake venom factor X-binding protein (X-bp) reduces hepatocyt...

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Dettagli Bibliografici
Autori principali: Liu, Ying, Wang, Hongjie, Yumul, Roma, Gao, Wentao, Gambotto, Andrea, Morita, Takashi, Baker, Andrew, Shayakhmetov, Dmitry, Lieber, André
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc. 2009
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Scientific Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828640/
https://ncbi.nlm.nih.gov/pubmed/19245296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2008.142
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