Transduction of Liver Metastases After Intravenous Injection of Ad5/35 or Ad35 Vectors With and Without Factor X-Binding Protein Pretreatment

Inefficient tumor transduction with targeted adenoviral vectors is largely due to unspecific virus sequestration by blood components, including coagulation factor X, and Kupffer cell scavenging. In this study, we show that preinjection of snake venom factor X-binding protein (X-bp) reduces hepatocyt...

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Bibliografiske detaljer
Main Authors: Liu, Ying, Wang, Hongjie, Yumul, Roma, Gao, Wentao, Gambotto, Andrea, Morita, Takashi, Baker, Andrew, Shayakhmetov, Dmitry, Lieber, André
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2009
Fag:
Scientific Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828640/
https://ncbi.nlm.nih.gov/pubmed/19245296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2008.142
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