Influence of Coagulation Factor X on In Vitro and In Vivo Gene Delivery by Adenovirus (Ad) 5, Ad35, and Chimeric Ad5/Ad35 Vectors

The binding of coagulation factor X (FX) to the hexon of adenovirus (Ad) 5 is pivotal for hepatocyte transduction. However, vectors based on Ad35, a subspecies B Ad, are in development for cancer gene therapy, as Ad35 utilizes CD46 (which is upregulated in many cancers) for transduction. We investig...

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Bibliographische Detailangaben
Hauptverfasser: Greig, Jenny A, Buckley, Suzanne MK, Waddington, Simon N, Parker, Alan L, Bhella, David, Pink, Rebecca, Rahim, Ahad A, Morita, Takashi, Nicklin, Stuart A, McVey, John H, Baker, Andrew H
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2009
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835023/
https://ncbi.nlm.nih.gov/pubmed/19603000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.152
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