A map of open chromatin in human pancreatic islets

Tissue-specific transcriptional regulation is central to human disease1. To identify regulatory DNA active in human pancreatic islets, we profiled chromatin by FAIRE (Formaldehyde-Assisted Isolation of Regulatory Elements)2–4 coupled with high-throughput sequencing. We identified ~80,000 open chroma...

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Autors principals: Gaulton, Kyle J., Nammo, Takao, Pasquali, Lorenzo, Simon, Jeremy M., Giresi, Paul G., Fogarty, Marie P., Panhuis, Tami M., Mieczkowski, Piotr, Secchi, Antonio, Bosco, Domenico, Berney, Thierry, Montanya, Eduard, Mohlke, Karen L., Lieb, Jason D., Ferrer, Jorge
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828505/
https://ncbi.nlm.nih.gov/pubmed/20118932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.530
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