Simultaneous haploinsufficiency of Pten and Trp53 tumor suppressor genes accelerates tumorigenesis in a mouse model of prostate cancer

Tumor suppressor gene PTEN is important in the initiation and progression of human prostate carcinoma, whereas the role of TP53 remains controversial. Since Pten/Trp53 double conditional knockout mice show earlier onset and fast progression of prostate cancer when compared to Pten knockout mice, we...

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Detalhes bibliográficos
Main Authors: Couto, Suzana S., Cao, Mei, Duarte, Paulo C., Banach-Petrosky, Whitney, Wang, Shunyou, Romanienko, Peter, Wu, Hong, Cardiff, Robert D., Abate-Shen, Cory, Cunha, Gerald R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828345/
https://ncbi.nlm.nih.gov/pubmed/19281769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.diff.2008.09.010
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