STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease

Phosphorylated signal transducer and activator of transcription 5 (STAT5) is a biomarker and potential molecular target for hematologic malignancies. We have shown previously that lethal myeloproliferative disease (MPD) in mice mediated by persistently activated STAT5 (STAT5a(S711F)) requires the N-...

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Main Authors: Li, Geqiang, Miskimen, Kristy L., Wang, Zhengqi, Xie, Xiu Yan, Brenzovich, Jennifer, Ryan, John J., Tse, William, Moriggl, Richard, Bunting, Kevin D.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2010
Teme:
Myeloid Neoplasia
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826763/
https://ncbi.nlm.nih.gov/pubmed/20008792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-07-234963
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