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Fibulin-4 deficiency results in ascending aortic aneurysms: a potential link between abnormal smooth muscle cell phenotype and aneurysm progression

RATIONALE: Loss of fibulin-4 during embryogenesis results in perinatal lethality due to aneurysm rupture, and defective elastic fiber assembly has been proposed as an underlying cause for the aneurysm phenotype. However, aneurysms are never seen in mice deficient for elastin, or for fibulin-5, which...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Huang, Jianbin, Davis, Elaine C., Chapman, Shelby L., Budatha, Madhusudhan, Marmorstein, Lihua Y., Word, R. Ann, Yanagisawa, Hiromi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826613/
https://ncbi.nlm.nih.gov/pubmed/20019329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.207852
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