Orally Bioavailable Anti-HBV Dinucleotide Acyloxyalkyl Prodrugs

The acyloxyalkyl derivatives of a model anti-HBV dinucleotide were synthesized and evaluated as orally bioavailable prodrugs. Our studies have led to the identification of the first orally bioavailable dinucleotide prodrugs for further therapeutic development against the hepatitis B virus (HBV).

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Detalhes bibliográficos
Main Authors: Coughlin, John E., Padmanabhan, Seetharamaiyer, Zhang, Guangrong, Kirk, Cassandra J., Govardhan, Chandrika P., Korba, Brent E., O'Loughlin, Kathleen, Green, Carol E., Mirsalis, Jon, Morrey, John D., Iyer, Radhakrishnan P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826611/
https://ncbi.nlm.nih.gov/pubmed/20117930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.01.010
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