Orally Bioavailable Anti-HBV Dinucleotide Acyloxyalkyl Prodrugs

The acyloxyalkyl derivatives of a model anti-HBV dinucleotide were synthesized and evaluated as orally bioavailable prodrugs. Our studies have led to the identification of the first orally bioavailable dinucleotide prodrugs for further therapeutic development against the hepatitis B virus (HBV).

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Dades bibliogràfiques
Autors principals: Coughlin, John E., Padmanabhan, Seetharamaiyer, Zhang, Guangrong, Kirk, Cassandra J., Govardhan, Chandrika P., Korba, Brent E., O'Loughlin, Kathleen, Green, Carol E., Mirsalis, Jon, Morrey, John D., Iyer, Radhakrishnan P.
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826611/
https://ncbi.nlm.nih.gov/pubmed/20117930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.01.010
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