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X-ray Structure of Human Aromatase Reveals An Androgen-Specific Active Site

Aromatase is a unique cytochrome P450 that catalyzes the removal of the 19-methyl group and aromatization of the A-ring of androgens for the synthesis of estrogens. All human estrogens are synthesized via this enzymatic aromatization pathway. Aromatase inhibitors thus constitute a frontline therapy...

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Detalhes bibliográficos
Main Authors: Ghosh, Debashis, Griswold, Jennifer, Erman, Mary, Pangborn, Walter
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826573/
https://ncbi.nlm.nih.gov/pubmed/19808095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2009.09.012
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