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X-ray Structure of Human Aromatase Reveals An Androgen-Specific Active Site
Aromatase is a unique cytochrome P450 that catalyzes the removal of the 19-methyl group and aromatization of the A-ring of androgens for the synthesis of estrogens. All human estrogens are synthesized via this enzymatic aromatization pathway. Aromatase inhibitors thus constitute a frontline therapy...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2826573/ https://ncbi.nlm.nih.gov/pubmed/19808095 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2009.09.012 |
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