The mechanism of a neurotransmitter:sodium symporter – inward release of Na(+) and substrate is triggered by substrate in a second binding site

Eukaryotic neurotransmitter:Na(+) symporters (NSS), targets for antidepressants and psychostimulants, terminate neurotransmission by sodium-driven reuptake. The crystal structure of LeuT(Aa), a prokaryotic NSS homolog, revealed an occluded state in which one leucine and two Na(+) ions are bound, but...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Shi, Lei, Quick, Matthias, Zhao, Yongfang, Weinstein, Harel, Javitch, Jonathan A.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826427/
https://ncbi.nlm.nih.gov/pubmed/18570870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.05.008
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares