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The role of transmembrane segment 5 (TM5) in Na2 release and the conformational transition of neurotransmitter:sodium symporters toward the inward-open state

Neurotransmitter:sodium symporters (NSSs) terminate neurotransmission by the reuptake of released neurotransmitters. This active accumulation of substrate against its concentration gradient is driven by the transmembrane Na(+) gradient and requires that the transporter traverses several conformation...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Stolzenberg, Sebastian, Li, Zheng, Quick, Matthias, Malinauskaite, Lina, Nissen, Poul, Weinstein, Harel, Javitch, Jonathan A., Shi, Lei
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418039/
https://ncbi.nlm.nih.gov/pubmed/28320858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.757153
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