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The mechanism of a neurotransmitter:sodium symporter – inward release of Na(+) and substrate is triggered by substrate in a second binding site
Eukaryotic neurotransmitter:Na(+) symporters (NSS), targets for antidepressants and psychostimulants, terminate neurotransmission by sodium-driven reuptake. The crystal structure of LeuT(Aa), a prokaryotic NSS homolog, revealed an occluded state in which one leucine and two Na(+) ions are bound, but...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2826427/ https://ncbi.nlm.nih.gov/pubmed/18570870 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.05.008 |
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