Relationship between Antibody 2F5 Neutralization of HIV-1 and Hydrophobicity of Its Heavy Chain Third Complementarity-Determining Region

The membrane-proximal external region (MPER) of the HIV-1 gp41 transmembrane glycoprotein is the target of the broadly neutralizing antibody 2F5. Prior studies have suggested a two-component mechanism for 2F5-mediated neutralization involving both structure-specific recognition of a gp41 protein epi...

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Detalhes bibliográficos
Main Authors: Ofek, Gilad, McKee, Krisha, Yang, Yongping, Yang, Zhi-Yong, Skinner, Jeff, Guenaga, F. Javier, Wyatt, Richard, Zwick, Michael B., Nabel, Gary J., Mascola, John R., Kwong, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826063/
https://ncbi.nlm.nih.gov/pubmed/20042512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02257-09
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