Structure and Mechanistic Analysis of the Anti-Human Immunodeficiency Virus Type 1 Antibody 2F5 in Complex with Its gp41 Epitope

The membrane-proximal region of the ectodomain of the gp41 envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1) is the target of three of the five broadly neutralizing anti-HIV-1 antibodies thus far isolated. We have determined crystal structures of the antigen-binding fragment for o...

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Publicado en:J Virol
Autores principales: Ofek, Gilad, Tang, Min, Sambor, Anna, Katinger, Hermann, Mascola, John R., Wyatt, Richard, Kwong, Peter D.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2004
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC516390/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15367639/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.19.10724-10737.2004
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