A tolC Mutant of Francisella tularensis Is Hypercytotoxic Compared to the Wild Type and Elicits Increased Proinflammatory Responses from Host Cells

The highly infectious bacterium Francisella tularensis is a facultative intracellular pathogen and the causative agent of tularemia. TolC, which is an outer membrane protein involved in drug efflux and type I protein secretion, is required for the virulence of the F. tularensis live vaccine strain (...

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Bibliographic Details
Main Authors: Platz, Gabrielle J., Bublitz, DeAnna C., Mena, Patricio, Benach, Jorge L., Furie, Martha B., Thanassi, David G.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Host Response and Inflammation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825903/
https://ncbi.nlm.nih.gov/pubmed/20028804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00992-09
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