Targeting Interleukin 6 Signaling Suppresses Glioma Stem Cell Survival and Tumor Growth

Glioblastomas (GBMs) are the most common and lethal primary brain tumor. Recent studies implicate an important role for a restricted population of neoplastic cells (glioma stem cells; GSCs) in glioma maintenance and recurrence. We now demonstrate that GSCs preferentially express the interleukin 6 (I...

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Detalhes bibliográficos
Main Authors: Wang, Hui, Lathia, Justin D., Wu, Qiulian, Wang, Jialiang, Li, Zhizhong, Heddleston, John M., Eyler, Christine E., Elderbroom, Jennifer, Gallagher, Joseph, Schuschu, Jesse, MacSwords, Jennifer, Cao, Yiting, McLendon, Roger E., Wang, Xiao-Fan, Hjelmeland, Anita B., Rich, Jeremy N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825688/
https://ncbi.nlm.nih.gov/pubmed/19658188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.188
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