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Cytoplasmic p53 and Activated Bax Regulate p53-dependent, Transcription-independent Neural Precursor Cell Apoptosis

The prodeath effects of p53 are typically mediated via its transcriptional upregulation of proapoptotic Bcl-2 family members, including PUMA, Noxa, and/or Bax. We previously reported that staurosporine (STS), a broad-spectrum kinase inhibitor and prototypical apoptosis-inducing agent, produced p53-d...

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Detalhes bibliográficos
Main Authors: Geng, Ying, Walls, K.C., Ghosh, Arindam P., Akhtar, Rizwan S., Klocke, Barbara J., Roth, Kevin A.
Formato: Artigo
Idioma:Inglês
Publicado em: Histochemical Society 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825492/
https://ncbi.nlm.nih.gov/pubmed/19901272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1369/jhc.2009.954024
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