Lysosome Dysfunction Triggers Atg7-dependent Neural Apoptosis

Macroautophagy (autophagy) is a process wherein bulk cytosolic proteins and damaged organelles are sequestered and degraded via the lysosome. Alterations in autophagy-associated proteins have been shown to cause neural tube closure defects, neurodegeneration, and tumor formation. Normal lysosome fun...

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Detalhes bibliográficos
Main Authors: Walls, Ken C., Ghosh, Arindam P., Franklin, Aimee V., Klocke, Barbara J., Ballestas, Mary, Shacka, John J., Zhang, Jianhua, Roth, Kevin A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856257/
https://ncbi.nlm.nih.gov/pubmed/20123985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.103747
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