The Ubiquitin Ligase Nedd4-1 Is Required for Heart Development and Is a Suppressor of Thrombospondin-1

Nedd4 (Nedd4-1) is a Hect domain E3 ubiquitin ligase that also contains a C2 domain and three WW domains. Despite numerous in vitro studies, its biological function in vivo is not well understood. Here we show that disruption of Nedd4-1 in mice (leaving Nedd4-2 intact) caused embryonic lethality at...

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Bibliografiska uppgifter
Huvudupphovsmän: Fouladkou, Fatemeh, Lu, Chen, Jiang, Chong, Zhou, Limei, She, Yimin, Walls, Jonathon R., Kawabe, Hiroshi, Brose, Nils, Henkelman, R. M., Huang, Annie, Bruneau, Benoit G., Rotin, Daniela
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2010
Ämnen:
Protein Synthesis and Degradation
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825471/
https://ncbi.nlm.nih.gov/pubmed/20026598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.082347
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