A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis

Obesity and insulin resistance are associated with deposition of triglycerides in tissues other than adipose tissue. Previously, we showed that a missense mutation (I148M) in PNPLA3 (patatin-like phospholipase domain-containing 3 protein) is associated with increased hepatic triglyceride content in...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: He, Shaoqing, McPhaul, Christopher, Li, John Zhong, Garuti, Rita, Kinch, Lisa, Grishin, Nick V., Cohen, Jonathan C., Hobbs, Helen H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2010
Pynciau:
Lipids
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825465/
https://ncbi.nlm.nih.gov/pubmed/20034933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.064501
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