A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis

Obesity and insulin resistance are associated with deposition of triglycerides in tissues other than adipose tissue. Previously, we showed that a missense mutation (I148M) in PNPLA3 (patatin-like phospholipase domain-containing 3 protein) is associated with increased hepatic triglyceride content in...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: He, Shaoqing, McPhaul, Christopher, Li, John Zhong, Garuti, Rita, Kinch, Lisa, Grishin, Nick V., Cohen, Jonathan C., Hobbs, Helen H.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2010
Gaiak:
Lipids
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825465/
https://ncbi.nlm.nih.gov/pubmed/20034933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.064501
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