Ebp1 Sumoylation, Regulated by TLS/FUS E3 Ligase, Is Required for its Anti-proliferative Activity

Ebp1, an ErbB3 receptor-binding protein, inhibits cell proliferation and acts as a putative tumor suppressor. Ebp1 translocates into the nucleus and functions as a transcription corepressor for E2F-1. Here, we show that Ebp1 p42 isoform can be sumoylated on both K93 and K298 residues, which mediate...

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Autori principali: Oh, Sang-Muk, Liu, Zhixue, Okada, Masashi, Jang, Sung-Wuk, Liu, Xia, Chan, Chi-Bun, Luo, Hongbo, Ye, Keqiang
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824779/
https://ncbi.nlm.nih.gov/pubmed/19946338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.411
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