Sumoylation of nucleophosmin/B23 regulates its subcellular localization, mediating cell proliferation and survival

Nucleophosmin/B23 is a major multifunctional nucleolar phosphoprotein that plays a critical role in ribosome biogenesis and cell proliferation. Arf tumor suppressor binds B23 and enhances its sumoylation. However, the biological effects of this event remain unknown. Here we show that B23 is sumoylat...

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Autors principals: Liu, Xia, Liu, Zhixue, Jang, Sung-Wuk, Ma, Zhiyong, Shinmura, Kazuya, Kang, Sumin, Dong, Shaozhong, Chen, Jing, Fukasawa, Kenji, Ye, Keqiang
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2007
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1887583/
https://ncbi.nlm.nih.gov/pubmed/17535915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701806104
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