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Ebp1 Sumoylation, Regulated by TLS/FUS E3 Ligase, Is Required for its Anti-proliferative Activity
Ebp1, an ErbB3 receptor-binding protein, inhibits cell proliferation and acts as a putative tumor suppressor. Ebp1 translocates into the nucleus and functions as a transcription corepressor for E2F-1. Here, we show that Ebp1 p42 isoform can be sumoylated on both K93 and K298 residues, which mediate...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2824779/ https://ncbi.nlm.nih.gov/pubmed/19946338 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.411 |
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