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Deletion of Ogg1 DNA glycosylase results in telomere base damage and length alteration in yeast
Telomeres consist of short guanine-rich repeats. Guanine can be oxidized to 8-oxo-7,8-dihydroguanine (8-oxoG) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG). 8-oxoguanine DNA glycosylase (Ogg1) repairs these oxidative guanine lesions through the base excision repair (BER) pathway. Here we s...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2824463/ https://ncbi.nlm.nih.gov/pubmed/19942858 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.355 |
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