BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly

Bardet-Biedl syndrome (BBS) is a human genetic disorder resulting in obesity, retinal degeneration, polydactyly, and nephropathy. Recent studies indicate that trafficking defects to the ciliary membrane are involved in this syndrome. Here, we show that a novel complex composed of three chaperonin-li...

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Главные авторы: Seo, Seongjin, Baye, Lisa M., Schulz, Nathan P., Beck, John S., Zhang, Qihong, Slusarski, Diane C., Sheffield, Val C.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2010
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824390/
https://ncbi.nlm.nih.gov/pubmed/20080638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910268107
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