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PARP-1 inhibition does not restore oxidant-mediated reduction in SIRT1 activity

Sirtuin1 (SIRT1) deacetylase and poly(ADP-ribose)-polymerase-1 (PARP-1) respond to environmental cues, and both require NAD(+) cofactor for their enzymatic activities. However, the functional link between environmental/oxidative stress-mediated activation of PARP-1 and SIRT1 through NAD(+) cofactor...

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Hlavní autoři: Caito, Samuel, Hwang, Jae-woong, Chung, Sangwoon, Yao, Hongwei, Sundar, Isaac K., Rahman, Irfan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824049/
https://ncbi.nlm.nih.gov/pubmed/20060806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.12.161
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