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Nrf2 Deficiency Influences Susceptibility to Steroid Resistance via HDAC2 reduction
Abnormal lung inflammation and oxidant burden are associated with a significant reduction in histone deacetylase 2 (HDAC2) abundance and steroid resistance. We hypothesized that Nrf2 regulates steroid sensitivity via HDAC2 in response to inflammation in mouse lung. Furthermore, HDAC2 deficiency lead...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3031165/ https://ncbi.nlm.nih.gov/pubmed/21094147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2010.11.054 |
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