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PARP-1 inhibition does not restore oxidant-mediated reduction in SIRT1 activity
Sirtuin1 (SIRT1) deacetylase and poly(ADP-ribose)-polymerase-1 (PARP-1) respond to environmental cues, and both require NAD(+) cofactor for their enzymatic activities. However, the functional link between environmental/oxidative stress-mediated activation of PARP-1 and SIRT1 through NAD(+) cofactor...
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| Hoofdauteurs: | , , , , , |
|---|---|
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2010
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2824049/ https://ncbi.nlm.nih.gov/pubmed/20060806 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.12.161 |
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