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Unexpected role of clathrin adaptor AP-1 in MHC-dependent positive selection of T cells
Trafficking of transmembrane receptors to a specific intracellular compartment is conducted by adaptor molecules that bind to target motifs within the cytoplasmic domains of cargo proteins. We generated mice containing a lymphoid-specific deficiency of AP-1 using RNAi knockdown technology. Inhibitio...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2823916/ https://ncbi.nlm.nih.gov/pubmed/20133794 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913671107 |
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