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Unexpected role of clathrin adaptor AP-1 in MHC-dependent positive selection of T cells

Trafficking of transmembrane receptors to a specific intracellular compartment is conducted by adaptor molecules that bind to target motifs within the cytoplasmic domains of cargo proteins. We generated mice containing a lymphoid-specific deficiency of AP-1 using RNAi knockdown technology. Inhibitio...

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Detalhes bibliográficos
Main Authors: Arias, Diana A. Alvarez, McCarty, Nami, Lu, Linrong, Maldonado, Roberto A., Shinohara, Mari L., Cantor, Harvey
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823916/
https://ncbi.nlm.nih.gov/pubmed/20133794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913671107
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