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Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism

To construct a versatile model host for heterologous expression of genes encoding secondary metabolite biosynthesis, the genome of the industrial microorganism Streptomyces avermitilis was systematically deleted to remove nonessential genes. A region of more than 1.4 Mb was deleted stepwise from the...

詳細記述

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書誌詳細
主要な著者: Komatsu, Mamoru, Uchiyama, Takuma, Ōmura, Satoshi, Cane, David E., Ikeda, Haruo
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823899/
https://ncbi.nlm.nih.gov/pubmed/20133795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914833107
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