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Ca(2+) Binding to Site I of the Cardiac Ca(2+) Pump Is Sufficient to Dissociate Phospholamban

Phospholamban (PLB) inhibits the activity of SERCA2a, the Ca(2+)-ATPase in cardiac sarcoplasmic reticulum, by decreasing the apparent affinity of the enzyme for Ca(2+). Recent cross-linking studies have suggested that PLB binding and Ca(2+) binding to SERCA2a are mutually exclusive. PLB binds to the...

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書目詳細資料
Main Authors: Chen, Zhenhui, Akin, Brandy L., Jones, Larry R.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823463/
https://ncbi.nlm.nih.gov/pubmed/19948724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.080820
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