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Ca(2+) Binding to Site I of the Cardiac Ca(2+) Pump Is Sufficient to Dissociate Phospholamban
Phospholamban (PLB) inhibits the activity of SERCA2a, the Ca(2+)-ATPase in cardiac sarcoplasmic reticulum, by decreasing the apparent affinity of the enzyme for Ca(2+). Recent cross-linking studies have suggested that PLB binding and Ca(2+) binding to SERCA2a are mutually exclusive. PLB binds to the...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2823463/ https://ncbi.nlm.nih.gov/pubmed/19948724 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.080820 |
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