Yüklüyor......
The transcription-independent mitochondrial p53 program is a major contributor to nutlin-induced apoptosis in tumor cells
Strategies to induce p53 activation in tumors that retain wild-type p53 are promising for cancer therapy. Nutlin is a potent and selective pharmacological MDM2 inhibitor that competitively binds to its p53-binding pocket, thereby leading to non-genotoxic p53 stabilization and activation of growth ar...
Kaydedildi:
| Asıl Yazarlar: | , , |
|---|---|
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2009
|
| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2823264/ https://ncbi.nlm.nih.gov/pubmed/19411846 |
| Etiketler: |
Etiketle
Etiket eklenmemiş, İlk siz ekleyin!
|