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Molecular mechanisms of nutlin-induced apoptosis in multiple myeloma: Evidence for p53-transcription-dependent and -independent pathways

Multiple myeloma (MM) is an incurable plasma cell malignancy in which p53 is rarely mutated. Thus, activation of the p53 pathway by a small molecule inhibitor of the p53-MDM2 interaction, nutlin, in MM cells retaining wild type p53 is an attractive therapeutic strategy. Recently we reported that nut...

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Detalhes bibliográficos
Main Authors: Saha, Manujendra N, Jiang, Hua, Chang, Hong
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040946/
https://ncbi.nlm.nih.gov/pubmed/20595817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.10.6.12535
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