Multiple Genetic Mechanisms Lead to Loss of Functional TbAT1 Expression in Drug-Resistant Trypanosomes

The P2 aminopurine transporter, encoded by TbAT1 in African trypanosomes in the Trypanosoma brucei group, carries melaminophenyl arsenical and diamidine drugs into these parasites. Loss of this transporter contributes to drug resistance. We identified the genomic location of TbAT1 to be in the subte...

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Autori principali: Stewart, Mhairi L., Burchmore, Richard J. S., Clucas, Caroline, Hertz-Fowler, Christiane, Brooks, Karen, Tait, A., MacLeod, A., Turner, C. Michael R., De Koning, Harry P., Wong, Pui Ee, Barrett, Michael P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823006/
https://ncbi.nlm.nih.gov/pubmed/19966032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/EC.00200-09
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