Multiple Genetic Mechanisms Lead to Loss of Functional TbAT1 Expression in Drug-Resistant Trypanosomes

The P2 aminopurine transporter, encoded by TbAT1 in African trypanosomes in the Trypanosoma brucei group, carries melaminophenyl arsenical and diamidine drugs into these parasites. Loss of this transporter contributes to drug resistance. We identified the genomic location of TbAT1 to be in the subte...

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Main Authors: Stewart, Mhairi L., Burchmore, Richard J. S., Clucas, Caroline, Hertz-Fowler, Christiane, Brooks, Karen, Tait, A., MacLeod, A., Turner, C. Michael R., De Koning, Harry P., Wong, Pui Ee, Barrett, Michael P.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823006/
https://ncbi.nlm.nih.gov/pubmed/19966032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/EC.00200-09
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